The association of hypogonadism with depression and its treatments

According to World Health Organization estimates, 5% of the adult population worldwide suffers from depression. In addition affective, psychomotor and cognitive symptoms which characterize this mood disorder, sexual dysfunction has been frequently reported among men suffering The most common manifestations are decreased libido, erectile orgasmic disorder. addition, epidemiological studies have documented a reduction testosterone concentrations in with depression and, for these reasons, depressive disorders appear as one possible cause male functional hypogonadism. Moreover, some largely used antidepressant medications can or worsen complaints, thus its treatments rise several andrological-relevant issues. other way round, hypogonadism manifest depressed mood, anxiety, insomnia, memory impairment which, if mild, may respond replacement therapy (TRT). However, prevalence depression, hypogonadal men, is not known. Severe do TRT, while effect treating major on hypogonadism, investigated. Overall, clinical relevance each condition other, well physiopathological underpinnings their relationship, still be clarified. present review summarizes current evidence influence hypothalamic-pituitary-testis axis; association between depression; reciprocal effects respective treatments.